Benjamin D. Humphreys, MD, PhD
Joseph Friedman Professor of Renal Diseases in Medicine and Chief, Division of Nephrology
Patients seen at
4921 Parkview Place
Suite C, 5th Floor
St. Louis, MO 63110
- Undergraduate: Harvard College, Cambridge, MA, (1991)
- MD, PhD: Case Western Reserve University, Cleveland, OH, (2000)
- Internal Medicine Residency: Massachusetts General Hospital, Boston, MA, (2002)
- Nephrology Fellowship: Brigham and Women's Hospital, Boston, MA, (2005)
- Nephrology: Board Certified
Gottschalk Award, American Society of Nephrology
American Society of Clinical Investigation
Established Investigator, American Heart Association
Regular Member, Pathobiology of Kidney Disease study section, National Institutes of Health
The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney regeneration and thereby identify new therapeutic strategies for humans suffering from kidney disease. A primary focus is on stem cell-based therapeutic approaches. We use mouse as a model system as well as human pluripotent stem cells. The work encompasses two main areas:
- Developing stem cell-based approaches to treat kidney disease in humans.
- Understanding the mechanisms of kidney repair and recovery after injury.
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell. 2016 Nov 3;19(5):628-642. doi: 10.1016/j.stem.2016.08.001. Epub 2016 Sep 8.
Humphreys BD. Mechanisms of Renal Fibrosis. Annu Rev Physiol. 2018 Feb 10;80:309-326. doi: 10.1146/annurev-physiol-022516-034227. Epub 2017 Oct 25.
Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD. Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight. 2018 May 3;3(9). pii: 99561. doi: 10.1172/jci.insight.99561. [Epub ahead of print]
R. Kramann, S.V. Fleig, R.K. Schneider, S.L. Fabian, D.P. DiRocco, O.H. Maarouf, J. Wongboonsin, Y. Ikeda, D. Heckl, S.L. Chang, H.G. Rennke, S.S. Waikar and B.D. Humphreys. Gli2 regulates myofibroblast cell-cycle progression in kidney fibrosis and is a novel therapeutic target. J Clin Invest, 2015, 125(8):2935-51.
O.H Maarouf, A. Aravamudhan, D. Rangarajan, T. Kusaba, V. Zhang, J. Welborn, D. Gauvin, X. Hou, R. Kramann and B.D. Humphreys. Paracrine Wnt1 drives interstitial fibrosis without inflammation by tubulo-interstitial crosstalk. J Am Soc Nephrol, 2015, Epub ahead of print.
R. Kramann, R.K. Schneider, D.P. DiRocco, F. Machado, S.V. Fleig, P.A. Bondzie, J.M. Henderson, B.L. Ebert and B.D. Humphreys. Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell, 2015; 16(1):51-66.
I. Grgic, A.F. Hofmeister, G. Genovese, A.J. Bernhardy, H. Sun, O.H. Maarouf, V. Bijol, M.R. Pollak and B.D. Humphreys. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney Int, 2014; 86(6):1116-29.
T. Kusaba, M. Lalli, R. Kramann, A. Kobayashi and B.D. Humphreys. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Nat Acad Sci, 2014;111(4)1527-32.
I. Grgic, A.M. Krautzberger, A. Hofmeister, M. Lalli, D.P. DiRocco, S.V. Fleig, J. Liu, J.S. Duffield, A.P. McMahon, B. Aronow and B.D. Humphreys. Translational profiles of medullary myofibroblasts during kidney fibrosis. J Am Soc Nephrol, 2014, 25(9):1979-90.
D. DiRocco, J. Bisi, P. Roberts, J. Strum, K. Wong, N. Sharpless and B.D. Humphreys. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. Am J Physiol: Renal, 2014, 306(4):F379-88.